Keywords: Diffusion Acquisition, New Signal Preparation Schemes, Spherical b-tensor encoding, oscillating gradient diffusion encoding
Motivation: Lack of spectral selectivity in spherical tensor diffusion encoding impairs the specificity of the measurement.
Goal(s): The goal of this work was to design diffusion gradient waveforms yielding a spherical b-tensor with frequency-specific and isotropic spectral projections.
Approach: Gradient waveform designs derived from oscillating gradient diffusion methodology were conceived by shifting and overlapping cosine-modulated trapezoidal oscillations along the three coordinate axes to achieve orthonormality of the b-tensor.
Results: The proposed gradient waveforms achieved frequency-specific and isotropic diffusion encoding, permitting frequency-dependent diffusion measurements in the in vivo human brain in the same manner as is conventionally performed using multidirectional linear tensor diffusion encoding.
Impact: The proposed diffusion gradient waveforms for spectrally specific and isotropic spherical tensor encoding offer selective frequency measurements that can isolate the signatures of time-dependent diffusion, thereby enabling the study of diffusion dispersion in the framework of tensor-valued encoding.
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