Keywords: Tumors (Pre-Treatment), CEST & MT
Motivation: In the setting of lower grade glioma follow heterogeneity of prognosis, it is currently necessitating risk stratification.
Goal(s): To determine the predictive ability of amide proton transfer-weighted (APTw) imaging phenotypes in lower grade glioma.
Approach: The ability of APTw phenotypes to PFS was evaluated using biomarker threshold model, The predictive model was trained on 67%, and tested on the remainder.
Results: APTw imaging phenotypes can predict the progression free survival of lower grade gliomas.
Impact: The independent and additional prognostic value of imaging phenotypes in APTw suggests that APTw imaging phenotypes can provide a noninvasive characterization of tumor cellular, proliferation and invasiveness to augment personalized prognosis and treatment in patients with lower grade glioma.
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