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Abstract #5176

White Matter Abnormalities in Multiple Sclerosis: A Network-Meta-Analysis of Diffusion Kurtosis Imaging Studies

Abdulmajeed Alotaibi1
1King Saud University for Health Sciences, Riyadh, Saudi Arabia

Synopsis

Motivation: We want to confirm MK's ability in MS by a meta-analysis because different research have reported contradicting outcomes of MK value (that can indicate axon and myelin microstructural complexity).

Goal(s): To compare DKI in WMLs and NAWM

Approach: Tabular pairwise comparison estimates for each category. Mean ranks, 95% confidence intervals, and cumulative ranking curve were shown.

Results: 3 studies evaluated MK in NAWM and WM among MS patients; 4 compared MK in WM among control and MS patients; and 5 compared MK in WM and NAWM as well.

Impact: The study found that MS WMLs and NAWM have lower MKs. The findings may help physicians evaluate MS WMLs using MK consistency.

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