Motivation: Lactate can be detected by both MRS and CEST. Compared to MRS, CEST imaging is faster due to its high sensitivity, but the low specificity limits it to qualitative study.
Goal(s): If deriving reliable quantitative maps from CEST Z-spectra is possible, the lactate imaging can be accelarated significantly.
Approach: On our rodent MRS and CEST dataset, we calculated the concentrations of lactate (and other metabolites) from single voxel MRS data as gold standard, and performed regression between them with the mean CEST Z-spectra of the same VOI.
Results: Preliminary results show lactate concentrations can be estimated by linear combination of Z-spectra.
Impact: Our preliminery work may provide a new insight into faster lactate imaging, that is, using a faster but less quantitative modality like CEST to acquire images and building the correlation of it with more reliable quantitative values.
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