Keywords: Magnetization Transfer, CEST & MT
Motivation: Together with specific CEST protons, Z-Spectrum Analysis Protons (ZAP) with an entire spectrum of broaden frequencies captures a wider range of exchange protons.
Goal(s): This study aims to develop a combined ZAP and CEST method to improve sensitivity to proton exchange variations for detecting pathological conditions.
Approach: Iopamidol and iohexol solutions with varying pH levels and human abdominal images at 3T were analyzed using a two-compartment model, while specific CEST protons were evaluated by MTRAsym.
Results: ZAP metrics demonstrated sensitivity to pH, effectively differentiating abdominal organs and detecting bile fluid alterations associated with gallstones, while MTRAsym successfully identified CEST exchange peaks.
Impact: Combining ZAP and CEST detects not only CEST protons but a wide spectrum of exchange protons. ZAP metrics demonstrate two proton exchange environments with good sensitivity. The combined CEST and ZAP outcomes indicates a possibility of biomarkers.
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