Abstract #0004

Spherical Echo-Planar Time-resolved Imaging (sEPTI) for rapid 3D quantitative T2* and susceptibility imaging

Nan Wang¹, Congyu Liao^1,2, Xiaozhi Cao^1,2, Mark Nishimura², Yannick WE Brackenier¹, Mahmut Yurt², Mengze Gao¹, Daniel Abraham², Cagan Alkan², Siddharth Srinivasan Iyer^1,3, Zihan Zhou¹, Hwihun Jeong⁴, Adam Kerr^2,5, Justin P. Halda⁶, and Kawin Setsompop^1,2

¹Department of Radiology, Stanford University, Stanford, CA, United States, ²Department of Electrical Engineering, Stanford University, Stanford, CA, United States, ³Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA, United States, ⁴Seoul National University, Seoul, Korea, Republic of, ⁵Cognitive and Neurobiological Imaging Center, Stanford University, Stanford, CA, United States, ⁶Ming Hsieh Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, CA, United States

Synopsis

Keywords: YIA, Acquisition Methods, Acquisition & analysis, Image reconstruction, Quantitative imaging, Machine Learning/Artificial Intelligence

Motivation: To improve the quality, resolution, and SNR, and reduce scan time by reducing averages for T2* and QSM at 3T

Goal(s): To develop a sEPTI technique that can achieve submillimeter high-quality T2* and QSM quantification in less than 90 seconds.

Approach: We developed: (1) an efficient less-correlated spherical EPTI sampling d; (2) an iterative B0 update pipeline for accurate and high SNR B0 map; (3) eddy-current correction to reduce artifacts; (4) a physics-informed unrolled network to boost the SNR.

Results: sEPTI achieved whole-brain 0.75-mm T2* and QSM quantification within a 90-second scan with the potential for wide clinical applications.

Impact: sEPTI technique was developed with synergetic improvements in sampling, B0 estimation, eddy-current correction, and unrolled-network reconstruction, which achieves whole-brain 0.75-mm distortion-free and blurring-free T2* and QSM quantification at 3T in 90 seconds with the potentials for wide clinical applications.

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