Keywords: YIA, Data Acquisition, Acquisition & Reconstruction, Acquisition Methods, Diffusion Acquisition
Motivation: Diffusion MRI faces challenges in achieving higher spatial resolution or b-values, including limited SNR, compromised image quality, and vulnerability to motion.
Goal(s): To overcome these major challenges and achieve efficient and robust high-resolution in-vivo dMRI and microstructure imaging.
Approach: We introduced Romer-EPTI, an SNR-efficient motion-robust acquisition technique, providing significant gain in SNR efficiency (e.g., 5×), high robustness to motion, and distortion-free imaging with minimal blurring and slab-boundary artifacts.
Results: We successfully achieved whole-brain in-vivo dMRI at mesoscale resolutions at both 3T (500-μm-iso) and 7T (485-μm-iso) using Romer-EPTI, and also demonstrated its high efficiency in high b-value microstructure imaging.
Impact: This study introduces a novel Romer-EPTI technique that addresses key challenges in in-vivo diffusion MRI acquisition to enable high-resolution dMRI at mesoscale spatial resolutions and efficient high-b-value microstructure imaging.
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