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Abstract #0007

Romer-EPTI: Rotating-View Motion-Robust Super-Res EPTI for SNR-Efficient Distortion-Free In-Vivo Mesoscale dMRI & Microstructure Imaging

Zijing Dong1,2, Timothy G. Reese1,2, Hong-Hsi Lee1,2, Susie Y. Huang1,2,3, Jonathan R. Polimeni1,2,3, Lawrence L. Wald1,2,3, and Fuyixue Wang1,2
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Department of Radiology, Harvard Medical School, Boston, MA, United States, 3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

Synopsis

Keywords: YIA, Data Acquisition, Acquisition & Reconstruction, Acquisition Methods, Diffusion Acquisition

Motivation: Diffusion MRI faces challenges in achieving higher spatial resolution or b-values, including limited SNR, compromised image quality, and vulnerability to motion.

Goal(s): To overcome these major challenges and achieve efficient and robust high-resolution in-vivo dMRI and microstructure imaging.

Approach: We introduced Romer-EPTI, an SNR-efficient motion-robust acquisition technique, providing significant gain in SNR efficiency (e.g., 5×), high robustness to motion, and distortion-free imaging with minimal blurring and slab-boundary artifacts.

Results: We successfully achieved whole-brain in-vivo dMRI at mesoscale resolutions at both 3T (500-μm-iso) and 7T (485-μm-iso) using Romer-EPTI, and also demonstrated its high efficiency in high b-value microstructure imaging.

Impact: This study introduces a novel Romer-EPTI technique that addresses key challenges in in-vivo diffusion MRI acquisition to enable high-resolution dMRI at mesoscale spatial resolutions and efficient high-b-value microstructure imaging.

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Keywords