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Abstract #0019

Respiration is a driver for parenchyma hydrodynamics: insights from dynamic DWI

Jianing Zhang1, Elodie Foster1, Xiaopeng Zhou2, and Qiuting Wen1
1Department of Radiology and Imaging Sciences, Indiana University Indianapolis, Indianapolis, IN, United States, 2College of Health and Human Sciences, Purdue University, West Lafayette, IN, United States

Synopsis

Keywords: Neurofluids, DWI/DTI/DKI, Respiration, Parenchyma, Hydrodynamics

Motivation: The drivers of cerebrospinal and interstitial fluid dynamics in brain parenchyma remain debated, with respiration increasingly considered alongside cardiac pulsation.

Goal(s): To compare the roles of respiration and cardiac pulsation in driving the parenchyma hydrodynamics.

Approach: Dynamic diffusion-weighted imaging was employed to capture the incoherent fluid motion within the brain while suppressing the fast blood flow. Cross-correlation analysis evaluated its coupling with respiration and cardiac pulsation.

Results: Respiration was a stronger driver than cardiac pulsation in gray and white matter, whereas cardiac pulsation dominated in the paravascular subarachnoid space and ventricles.

Impact: This study highlights robust, respiration-driven hydrodynamics in the parenchyma, with inhalation slowing and exhalation accelerating fluid motion.

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Keywords