Keywords: Neurofluids, DWI/DTI/DKI, Respiration, Parenchyma, Hydrodynamics
Motivation: The drivers of cerebrospinal and interstitial fluid dynamics in brain parenchyma remain debated, with respiration increasingly considered alongside cardiac pulsation.
Goal(s): To compare the roles of respiration and cardiac pulsation in driving the parenchyma hydrodynamics.
Approach: Dynamic diffusion-weighted imaging was employed to capture the incoherent fluid motion within the brain while suppressing the fast blood flow. Cross-correlation analysis evaluated its coupling with respiration and cardiac pulsation.
Results: Respiration was a stronger driver than cardiac pulsation in gray and white matter, whereas cardiac pulsation dominated in the paravascular subarachnoid space and ventricles.
Impact: This study highlights robust, respiration-driven hydrodynamics in the parenchyma, with inhalation slowing and exhalation accelerating fluid motion.
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