Keywords: Deuterium, Deuterium, Spectroscopy, Tumors, metabolism
Motivation: Detecting both static and dynamic metabolism through ¹H MRSI and DMI can provide valuable insights into tumor biology. However, reliable detection of lactate (Lac) in tumors using ¹H MRSI is often compromised by lipid contamination.
Goal(s): Develop an interleaved edited ¹H MRSI-DMI sequence that allows parallel acquisition of both 1H MRSI and DMI, and robustly detect 1H-Lac in the presence of lipids, to provide insights into tumor metabolism.
Approach: Seven 2H-scans could be acquired in parallel with every 1H MRS scan as validated in vitro and demonstrated in vivo.
Results: The combined 1H MRSI-DMI successfully revealed key tumor-associated static(tCho,NAA,Lac) and dynamic(2H-Glx,2H-Lac) metabolic changes.
Impact: The interleaved edited 1H MRSI and DMI offers an opportunity to study and compare the static and active metabolism in parallel with robust 1H-Lac detection providing novel and complementary insights to the wide range of clinical MRI scans.
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