Abstract #0041

High resolution 3D Deuterium Metabolic Imaging of the human brain using bSSFP with concentric ring trajectory readout at 7T

Sabina Frese¹, Bernhard Strasser¹, Lukas Hingerl¹, Elton Montrazi², Lucio Frydman², Viola Bader¹, Anna Duguid¹, Aaron Osburg¹, Stanislav Motyka^1,3, Martin Krssak⁴, Thomas Scherer⁴, Rupert Lanzenberger⁵, Wolfgang Bogner^1,3, and Fabian Niess¹

¹High Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria, ²Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, Israel, ³Christian Doppler Laboratory for MR Imaging Biomarkers (BIOMAK), Vienna, Austria, ⁴Department of Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria, ⁵Department of Psychiatry and Psychotherapy, Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria

Synopsis

Keywords: Deuterium, Deuterium

Motivation: Deuterium metabolic imaging (DMI) suffers from inherently low SNR, which can be enhanced using balanced-steady-state-free-precession (bSSFP) pulse design. Higher SNR can be traded for increased spatial resolution using fast concentric ring trajectory (CRT) sampling.

Goal(s): To develop and implement a 3D-bSSFP-DMI sequence for whole-brain DMI in humans at 7T.

Approach: A bSSFP sequence module was combined with 3D-CRT sampling and metabolic maps of water/glucose/glutamate+glutamine were dynamically acquired in 4 healthy volunteers.

Results: A 2-4-fold SNR increase was observed for DMI maps using bSSFP-DMI compared to FID-CRT-DMI, which allowed for increased spatial resolution (0.75ml to 0.36ml), while maintaining sufficient quality.

Impact: Improving SNR and consequently spatial resolution of deuterium metabolic imaging (DMI) data is crucial to push DMI towards clinical application. bSSFP-CRT sequences combined with appropriate reconstruction and metabolite separation can facilitate this transition.

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