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Abstract #0043

Respiratory motion corrected interleaved 23Na/1H pTx MRI of the human heart at 7 Tesla

Laurent Ruck1, Nico Egger1, Christoph Kopp2, Tobias Wilferth1, Simon Konstandin3, Michael Uder1, and Armin M. Nagel1,4
1Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 2Department of Nephrology and Hypertension, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 3Fraunhofer Institute for Digital Medicine MEVIS, Erlangen, Germany, 4Division of Medical Physics in Radiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany

Synopsis

Keywords: Non-Proton, Non-Proton, motion correction, Sodium MRI, 23Na MRI, interleaved 23Na/1H MRI

Motivation: Respiratory motion can falsify the quantified myocardial Na+ concentration in cardiac 23Na MRI and reduce inter-subject comparability.

Goal(s): To correct cardiac 23Na MR data for respiratory motion effects.

Approach: An interleaved 23Na/1H pTx sequence with 1H navigators was employed to reconstruct respiratory resolved 1H images. Appyling image co-registration of these 1H images, motion parameters were extracted for each respiratory motion state and used to perform respiratory motion correction for the corresponding 23Na MR data.

Results: The motion correction reduced the effect of respiratory motion on the 23Na MR data, while providing a higher SNR than conventional respiratory motion sorting.

Impact: Interleaved 23Na/1H pTx MRI allows to perform respiratory motion correction of the 23Na MR data based on the additional 1H MR data. This could enhance the accuracy of myocardial Na+ quantification and improve inter-subject comparability.

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