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Abstract #0052

Inflammatory-targeted iron oxide nanoparticles contrast agent for magnetic resonance imaging of atherosclerotic plaques

Lele Ma1, Nan Gao1, Teng Gong1, Xiaolei Song1, Haiming Fan2, and Huan Zhang 2
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China, 2Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, China

Synopsis

Keywords: Atherosclerosis, Atherosclerosis

Motivation: Early-stage and precise identification of atherosclerotic (AS) vulnerable plaques are crucial for the prevention and treatment of acute cardiovascular adiseases.

Goal(s): Developing imaging nanoprobes to achieve early, accurate imaging and non-invasive dynamic monitoring of AS plaques.

Approach: A targeted probe was constructed by conjugating MT1-AF7p (HWKHLHNTKTFL) to the iron oxide (IO) nanoparticles. AS animal model was established using high-fat diet-fed ApoE-/- mice. The dynamic accumulation of the probe within plaques was monitored at 9.4 T MRI.

Results: The specificity of MT1-AF7p@IO nanoprobes to plaques was improved by nearly 2.1 times, and the average retention time was extended from 4 h to 8 h.

Impact: This study develops an imaging nanoprobe to enable early, precise imaging and non-invasive dynamic monitoring of the morphology and compositional properties of AS plaques. It has important clinical potential in facilitating early diagnosis, treatment, and therapeutic evaluation of cardiovascular diseases.

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