Abstract #0055

Assessing Right Heart Hemodynamics using 4D flow MRI in Chronic Obstructive Pulmonary Disease: The SPIROMICS HF Study

David Dushfunian¹, Timothy W. Houston², Michael Markl³, Oliver Wieben², Martin R. Prince⁴, Wei Shen⁵, James Carr³, David Bluemke², Michael Backman⁵, Sachin R. Jambawalikar⁵, Bharath Ambale Venkatesh⁶, Joao Lima⁶, Prachi Agarwal⁷, J. Paul Finn⁸, Christopher B. Cooper⁸, Yoo Jin Lee⁹, Joyce Schroeder¹⁰, Dalane W. Kitzman¹¹, R. Graham Barr⁵, and SPIROMICS Investigtors¹²

¹Department of Radiology, Northwestern University, chicago, IL, United States, ²University of Wisconsin-Madison, Madison, WI, United States, ³Northwestern University, Chicago, IL, United States, ⁴Columbia University Medical Center, New york, NY, United States, ⁵Columbia University Medical Center, New York, NY, United States, ⁶Johns Hopkins University, Baltimore, MD, United States, ⁷University of Michigan School of Medicine, Ann Arbor, MI, United States, ⁸University of California Los Angeles, Los Angeles, CA, United States, ⁹University of California San Francisco, San Francisco, CA, United States, ¹⁰University of Utah School of Medicine, Salt Lake City, UT, United States, ¹¹Wake Forest University, Winston-Salem, NC, United States, ¹²University of North Carolina, Chapel Hill, NC, United States

Synopsis

Keywords: Flow, Flow, COPD, hemodynamics, 4D flow MRI, heart failure, phase contrast imaging

Motivation: Studies have suggested correlations between heart failure and chronic obstructive pulmonary disease (COPD). However, the associations between cardiac hemodynamic impairment and lung function as well as COPD subtypes remain unclear.

Goal(s): To investigate cardiac hemodynamic changes seen in COPD, to gain insight into the mechanisms relating COPD and heart failure.

Approach: We analyzed 4D-flow derived hemodynamics in a cohort of 256 participants from the SPIROMICS-HF study.

Results: We found significant correlations between cardiac hemodynamics and COPD subtypes as well as other pulmonary function measures.

Impact: We present the potential of 4D flow MRI to non-invasively assess the cardiopulmonary hemodynamic interaction in COPD which may allow early detection and management of subclinical heart failure secondary to COPD.

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