Keywords: Tendon/Ligament, Quantitative Imaging, Achilles Tendon, Tendinopathy
Motivation: T1ρ mapping is a promising approach for imaging of Achilles Tendinopathy (AT), but imaging of short T2 components requires UTE-based sequences.
Goal(s): Evaluate our 3D magnetization-prepared UTE sequence to discriminate between AT patients from healthy subjects (HS) using bi-exponential (BE) models.
Approach: We scanned 6 HS and 4 AT patients with our UTE-T1ρ sequence. We performed mono-exponential (ME) and BE fitting. We used the linear discriminant analysis (LDA) to improve AT detection in the BE model. Wilcoxon rank-sum test was used to measure statistical significance.
Results: The composite T1ρ biomarker obtained with LDA in the BE model could discriminate AT patients from HS.
Impact: The study demonstrates that the T1ρ mapping obtained from magnetization-prepared 3D-UTE Sequence can potentially detect AT, particularly with BE relaxation models when combined with LDA.
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