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Abstract #0058

Ultra-short-echo time Sequence for Bi-exponential T1ρ Mapping of Achilles Tendinopathy

Anmol Monga1, Hector Lise de Moura2, Marcelo Wust Zibetti2, Smita Rao3,4, and Ravinder Regatte1
1Radiology, NYU Grossman School of Medicine, New York, NY, United States, 2NYU Grossman School of Medicine, New York, NY, United States, 3Department of Orthopedic Surgery, NYU Grossman School of Medicine, New York, NY, United States, 4Biomedical Engineering, NYU Tandon School of Engineering, New York, NY, United States

Synopsis

Keywords: Tendon/Ligament, Quantitative Imaging, Achilles Tendon, Tendinopathy

Motivation: T1ρ mapping is a promising approach for imaging of Achilles Tendinopathy (AT), but imaging of short T2 components requires UTE-based sequences.

Goal(s): Evaluate our 3D magnetization-prepared UTE sequence to discriminate between AT patients from healthy subjects (HS) using bi-exponential (BE) models.

Approach: We scanned 6 HS and 4 AT patients with our UTE-T1ρ sequence. We performed mono-exponential (ME) and BE fitting. We used the linear discriminant analysis (LDA) to improve AT detection in the BE model. Wilcoxon rank-sum test was used to measure statistical significance.

Results: The composite T1ρ biomarker obtained with LDA in the BE model could discriminate AT patients from HS.

Impact: The study demonstrates that the T1ρ mapping obtained from magnetization-prepared 3D-UTE Sequence can potentially detect AT, particularly with BE relaxation models when combined with LDA.

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