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Abstract #0060

Water specific T1 in Skeletal Muscle: Validation, Normative Values and the Confounding Influence of Fat

Stephen Foulkes1, Mark Haykowsky1, Rachel Sherrington1, Amy Kirkham2, Justin Grenier1, Peter Seres1, Christian Beaulieu1, David Ian Paterson3, and Richard Thompson1
1University of Alberta, Edmonton, AB, Canada, 2University of Toronto, Toronto, ON, Canada, 3Ottawa Heart Institute, Ottawa, ON, Canada

Synopsis

Keywords: Muscle, Muscle

Motivation: There is a need for water-specific T1 (T1Water) and fat quantification methods for detection of skeletal muscle fibrosis and fat infiltration.


Goal(s): Illustrate a saturation recovery chemical-shift encoded (SR-CSE) T1 mapping approach for skeletal muscle T1Water and fat content quantification (validation, reproducibility and normative values across sex and age).

Approach: SR-CSE scans were acquired in healthy adults (n=130) with spectroscopy validation studies and comparison to conventional T1 mapping methods.

Results: SR-CSE has excellent accuracy and reproducibility. Normative values (T1Water, Inter/Intramuscular fat and muscle volumes) were established (2.89T). Conventional T1 mapping methods have a significant T1 bias from intramuscular fat.

Impact: The SR-CSE approach jointly quantifies skeletal muscle fat and water-specific T1 (T1Water, removing T1 bias from fat), offering detection of muscle fibrosis and/or edema with co-existing fatty infiltration (e.g. sarcopenia).

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Keywords