Keywords: Tumors (Pre-Treatment), Tumors, Glioblastoma Multiforme; Magnetic Resonance Imaging; Thermoradiotherapy; Anoikis resistance; Melanin Nanoparticle.
Motivation:
Glioblastoma multiforme is a highly aggressive cancer, of which anoikis resistance contributes to the strong resistance to standard therapies resulting in a poor prognosis.
Goal(s): MRI-guided thermoradiotherapy is an attractive and innovative strategy for treating GBM, offering superior biocompatibility and therapeutic efficacy compared to conventional therapies.
Approach: Herein, we synthesized Gd-MNP-PEGs that present excellent MR imaging ability, photothermal conversion capability, and radiosensitizing effect.
Results: It contributes to i) MR imaging of GBM to identify tumor boundaries, ii) radiosensitizing GBM with photothermal therapy to inhibit the proliferation and metastasis of GBM, iii) reversing anoikis resistance via thermoradiotherapy to improve therapeutic outcomes.
Impact: This study presents biocompatible nanoplatforms that allow MR imaging, high anti-tumor thermoradiotherapy efficacy, and negligible side effects in the treatment of GBM.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords