Abstract #0072

In vivo proton MR spectroscopy reveals alterations in cysteine metabolism in human gliomas

Kimberly Chan^1,2, Evan K Noch^3,4, Elizabeth Maher^3,5, Toral Patel⁶, and Anke Henning^1,7

¹Advanced Imaging Research Center, The University of Texas Southwestern, Dallas, TX, United States, ²Department of Biomedical Engineering, University of Texas Southwestern Medical Center, Dallas, TX, United States, ³Department of Neurology, The University of Texas Southwestern, Dallas, TX, United States, ⁴Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁵Department of Internal Medicine, The University of Texas Southwestern, Dallas, TX, United States, ⁶Department of Neurological Surgery, The University of Texas Southwestern, Dallas, TX, United States, ⁷Department of Radiology, The University of Texas Southwestern, Dallas, TX, United States

Synopsis

Keywords: Tumors (Pre-Treatment), Tumors, Glioma, Cystathionine, Glutathione, Glutamate, Cysteine

Motivation: The cysteine metabolic pathway has been previously shown to be involved in the pathogenesis of gliomas and upregulated in glioblastomas relative to lower-grade gliomas.

Goal(s): The aim of this study was to investigate cysteine metabolism in glioma patients in vivo.

Approach: Edited ¹H-MRS targeting cystathionine was performed in twenty-nine patients with lesions radiographically consistent with gliomas.

Results: Cystathionine, glutamate, and glutathione were found to be higher in grade IV than in grade II/III tumors. Cystathionine and glutamate concentrations were also positively correlated with glutathione concentrations.

Impact: The measurement of dysregulated cysteine metabolism by 1H-MRS could provide a non-invasive biomarker for monitoring treatments that target this pathway, including cysteine depletion. High levels of cystathionine in the absence of 2HG could be a marker of IDH-wildtype glioblastoma.

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