Abstract #0074

Characterizing Intra- and Peritumoral Connectivity in Human Gliomas using Pseudo-Resting State Functional MRI Derived from DSC Perfusion MRI

Chencai Wang^1,2, Nicholas Cho^1,2,3, Jingwen Yao^1,2, Richard G Everson^4,5, Kunal S Patel^4,5, Linda M. Liau^4,5, Phioanh L. Nghiemphu^4,6, Noriko Salamon¹, Albert Lai^4,6, Timothy F. Cloughesy^4,6, and Benjamin M. Ellingson^1,2,3,4,7

¹Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, United States, ²UCLA Brain Tumor Imaging Laboratory (BTIL), Center for Computer Vision and Imaging Biomarkers, University of California, Los Angeles, CA, United States, ³Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, CA, United States, ⁴UCLA Neuro-Oncology Program, University of California, Los Angeles, CA, United States, ⁵Department of Neurosurgery, University of California, Los Angeles, CA, United States, ⁶Department of Neurology, University of California, Los Angeles, CA, United States, ⁷Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, United States

Synopsis

Keywords: Tumors (Pre-Treatment), Brain Connectivity, fMRI, Brain Tumor, IDH

Motivation: Clinical use of resting-state fMRI (rs-fMRI) to study brain tumor biology is not widespread, due in part by time and cost constraints.

Goal(s): Finding an alternative to traditional rs-fMRI for studying brain tumor biology and functional connectivity.

Approach: Deriving “pseudo” rs-fMRI from routine clinical DSC perfusion MRI, and using intra-tumoral connectivity (ITC) and dynamic time warping (DTW) distance to characterize tumor infiltration and heterogeneity.

Results: “Pseudo” rs-fMRI derived from clinical DSC perfusion MRI may be useful for monitoring brain tumor patients. ITC and peritumoral connectivity patterns are unique to different glioma molecular subtypes, suggesting differences in the underlying biology.

Impact: “Pseudo” rs-fMRI derived from clinical DSC perfusion MRI may be useful for monitoring brain tumor patients. Tumor infiltration and heterogeneity associated with different glioma molecular subtypes can be revealed by connectivity patterns within the tumor and with adjacent, normal-appearing tissue.

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