Abstract #0089

Stereotactic radiosurgery-induced changes in brain metastasis patients within two weeks after therapy detected using multi-parametric qMRI

Dennis C. Thomas^1,2,3,4, Svenja Klinsing^2,5,6, Mariem Ghazouani¹, Anna-Luisa Luger^2,3,4,6, Robert Wolff^2,3,4,7, Markus Czabanka^2,3,4,8, Joachim P. Steinbach^2,3,4,6, Ulrich Pilatus¹, Elke Hattingen^1,2,3,4, Pia S. Zeiner^2,3,4,5,6, and Katharina J. Wenger^1,2,3,4

¹Goethe University Frankfurt, University Hospital Frankfurt, Institute of Neuroradiology, Frankfurt am Main, Germany, ²University Cancer Center Frankfurt (UCT), Frankfurt, Frankfurt am Main, Germany, ³Frankfurt Cancer Institute (FCI), Frankfurt am Main, Germany, ⁴German Cancer Research Center (DKFZ) Heidelberg and German Cancer Consortium (DKTK), Heidelberg, Germany, ⁵Goethe University Frankfurt, University Hospital Frankfurt, Department of Neurology, Frankfurt am Main, Germany, ⁶Goethe University Frankfurt, University Hospital Frankfurt, Dr. Senckenberg Institute of Neurooncology, Frankfurt am Main, Germany, ⁷Goethe University Frankfurt, University Hospital Frankfurt, Department of Radiation Therapy, Frankfurt am Main, Germany, ⁸Goethe University Frankfurt, University Hospital Frankfurt, Department of Neurosurgery, Frankfurt am Main, Germany

Synopsis

Keywords: Tumors (Post-Treatment), Quantitative Imaging, Multi-parametric Quantitative MRI, Stereotactic Radiotherapy

Motivation: Pre-operative stereotactic radiosurgery (SRS) is routinely included in brain metastases (BM) treatment. Early changes in tumor/surrounding tissue after SRS could predict patient outcome but have rarely been reported.

Goal(s): Examine early (<2 weeks) qualitative (weighted-images) and quantitative (multi-parametric qMRI) changes in BM after pre-operative SRS.

Approach: Six patients were scanned before and after SRS with a standardized Brain Tumor Imaging (BTIP) and mp-qMRI protocol.

Results: Contrast-enhanced tumor mask volumes increased for most patients. The oedema-mask volumes, decreased for 50% and increased for 50% of the total patients. Volume changes corresponded to changes in qMRI. qMRI changes did not significantly correlate with radiation dose.

Impact: Results demonstrate that qualitative and quantitative (qMRI) changes are detectable in MR scans of BM patients even within two weeks after SRS. The effects of SRS are not dose dependent and may have predictive value for treatment outcome.

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