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Abstract #0127

Experimental investigation of a simple estimate of axon size

Hannah Alderson1,2, Mark Does1,2,3, and Kevin Harkins1,2,3
1Biomedical Engineering, Vanderbilt, Nashville, TN, United States, 2Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, 3Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States

Synopsis

Keywords: Microstructure, Spinal Cord

Motivation: Changes in radial diffusivity with diffusion time have been suggested to correlate with axon diameter but has not yet been experimentally evaluated with MRI and histology.

Goal(s): This work aims to experimentally compare diffusion-time difference in radial diffusivity with histology measures of axon diameter.

Approach: Diffusion time dependent radial diffusivity and axon diameter were measured in ex vivo spinal cords via MRI and scanning electron microscopy acquisitions, respectively.

Results: Diffusion-time difference in radial diffusivity showed a strong linear correlation (r = 0.923) with histology derived estimates of mean axon diameter in ex vivo ferret spinal cord.

Impact: Diffusion time difference in radial diffusivity is shown in this work to correlate well with histology derived axon diameter. Importantly, it is straightforward to measure and therefore provides a simple estimate of axon diameter.

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Keywords