Keywords: Microstructure, Spinal Cord
Motivation: Changes in radial diffusivity with diffusion time have been suggested to correlate with axon diameter but has not yet been experimentally evaluated with MRI and histology.
Goal(s): This work aims to experimentally compare diffusion-time difference in radial diffusivity with histology measures of axon diameter.
Approach: Diffusion time dependent radial diffusivity and axon diameter were measured in ex vivo spinal cords via MRI and scanning electron microscopy acquisitions, respectively.
Results: Diffusion-time difference in radial diffusivity showed a strong linear correlation (r = 0.923) with histology derived estimates of mean axon diameter in ex vivo ferret spinal cord.
Impact: Diffusion time difference in radial diffusivity is shown in this work to correlate well with histology derived axon diameter. Importantly, it is straightforward to measure and therefore provides a simple estimate of axon diameter.
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