Keywords: DWI/DTI/DKI, DWI/DTI/DKI, OGSE, frequency dependence, microstructure, kurtosis, exchange, human brain
Motivation: In vivo evaluation of membrane integrity has been achieved through diffusion frequency-dependence, measured by using oscillating-gradient spin-echo (OGSE) sequence. However, the observed frequency-dependence in previous studies is inconsistent due to two different ways of varying frequency.
Goal(s): To compare and interpret the frequency-dependent kurtosis, measured by using OGSE of varying frequency with either (1) a fixed number of oscillations or (2) a fixed total waveform time.
Approach: We performed in vivo frequency-dependent kurtosis measurements in brains by using OGSE in two approaches and explained results based on adiabatic Kärger exchange model.
Results: The theory coincided with observations and yielded membrane exchange time estimations.
Impact: We measured frequency-dependent kurtosis in human brains using oscillating-gradient-spin-echo sequence with either a fixed number of oscillations or a fixed total waveform time. The observed kurtosis frequency-dependence in two approaches were orthogonal, providing a novel way to evaluate water exchange.
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