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Abstract #0135

Revealing membrane integrity in human brain using oscillating-gradient diffusion sequence in two frequency-varying regimes

Dongsuk Sung1, Wen Zhong2, Jialan Zheng3, Qiyuan Tian2,4, Susie Y. Huang1, and Hong-Hsi Lee1
1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, 2School of Biomedical Engineering, Tsinghua University, Beijing, China, 3Tanwei College, Tsinghua University, Beijing, China, 4Tsinghua Laboratory of Brain and Intelligence, Tsinghua University, Beijing, China

Synopsis

Keywords: DWI/DTI/DKI, DWI/DTI/DKI, OGSE, frequency dependence, microstructure, kurtosis, exchange, human brain

Motivation: In vivo evaluation of membrane integrity has been achieved through diffusion frequency-dependence, measured by using oscillating-gradient spin-echo (OGSE) sequence. However, the observed frequency-dependence in previous studies is inconsistent due to two different ways of varying frequency.

Goal(s): To compare and interpret the frequency-dependent kurtosis, measured by using OGSE of varying frequency with either (1) a fixed number of oscillations or (2) a fixed total waveform time.

Approach: We performed in vivo frequency-dependent kurtosis measurements in brains by using OGSE in two approaches and explained results based on adiabatic Kärger exchange model.

Results: The theory coincided with observations and yielded membrane exchange time estimations.

Impact: We measured frequency-dependent kurtosis in human brains using oscillating-gradient-spin-echo sequence with either a fixed number of oscillations or a fixed total waveform time. The observed kurtosis frequency-dependence in two approaches were orthogonal, providing a novel way to evaluate water exchange.

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