Keywords: Epilepsy, Focused Ultrasound, hippocampus
Motivation: Previous transcranial focused ultrasound (FUS) studies show that FUS modulates the gamma-aminobutyric acid (GABA) levels in the cingulate cortex and increases the functional connectivity to and associated with the FUS targets at cortex.
Goal(s): Examine the neuromodulatory effects of FUS on the human hippocampus.
Approach: Low-intensity FUS was applied to the left hippocampus of four medically refractory patients. Hippocampal functional connectivity was measured before and after FUS using seed-based correlation.
Results: Significantly increased functional connectivity to the left hippocampus was found after FUS. FUS significantly decreased the hippocampal functional connectivity at the left precuneus, and right prefrontal cortex (mPFC)
Impact: We presented neuroplastic evidence of functional connectivity change induced by FUS at the human hippocampus. Our results show the re-organization of the functional connectivity with changes within (precunues and medial prefrontal cortex) and beyond typical nodes in the hippocampal network.
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