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Abstract #0144

Human functional network modulated by focused ultrasonic stimulation of the hippocampus

Hsin-Ju Lee1,2, Jia-Hung Hsieh3, Hsiang-Yu Yu4,5, Chen-Jia Lee4,5, Chien-Chen Chou4,5, Yen-Cheng Shih4, Po-Tso Lin4, Wen-Jui Kuo3, and Fa-Hsuan Lin1,2
1Sunnybrook Research Institute, Toronto, ON, Canada, 2Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, Taiwan, 4Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, 5School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan

Synopsis

Keywords: Epilepsy, Focused Ultrasound, hippocampus

Motivation: Previous transcranial focused ultrasound (FUS) studies show that FUS modulates the gamma-aminobutyric acid (GABA) levels in the cingulate cortex and increases the functional connectivity to and associated with the FUS targets at cortex.

Goal(s): Examine the neuromodulatory effects of FUS on the human hippocampus.

Approach: Low-intensity FUS was applied to the left hippocampus of four medically refractory patients. Hippocampal functional connectivity was measured before and after FUS using seed-based correlation.

Results: Significantly increased functional connectivity to the left hippocampus was found after FUS. FUS significantly decreased the hippocampal functional connectivity at the left precuneus, and right prefrontal cortex (mPFC)

Impact: We presented neuroplastic evidence of functional connectivity change induced by FUS at the human hippocampus. Our results show the re-organization of the functional connectivity with changes within (precunues and medial prefrontal cortex) and beyond typical nodes in the hippocampal network.

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Keywords