Keywords: Microstructure, Brain, Histology
Motivation: The human cerebellum is relevant across cognitive domains. However, in-vivo cerebellar MRI measures are lacking, due to resolution/analysis constraints. Consequently, the cerebellar morphology and its links to cytoarchitecture are unexplored, thus limiting neuroscientific research.
Goal(s): To develop in-vivo cerebellar cortical measures and probe their biological relevance.
Approach: We combined motion-corrected, RF-shimmed, 7T-MRI with a novel segmentation pipeline. We extracted regional cytoarchitectonic features from 3D-reconstructed histological and immunohistochemical data.
Results: Regional differences in cerebellar cortical thickness correlated with granular layer cell density, while vascular measures also correlated with cortical thickness and cytoarchitecture.
Impact: The detailed human cerebellar morphology is unexplored. Here, we combine motion-corrected, RF-shimmed 7T-MRI with a novel segmentation approach to demonstrate links between in-vivo/post-mortem cerebellar morphology, vasculature and cytoarchitecture. This may provide insights into the pathology of several neurological disorders.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords