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Abstract #0148

Linking the cerebellar morphology with cytoarchitecture using motion-corrected, RF-shimmed, 7T MRI

Nikos Priovoulos1,2,3, Pilou L Bazin4, Emma J P Brouwer3,5, Jorje F Mejias6,7, Matthijs H S de Buck3,8, Anneke Alkemade9, Wietske van der Zwaag3,5, and Matthan W A Caan2
1Wellcome Centre for Intergrative Neuroimaging, Oxford, United Kingdom, 2Department of Biomedical Engineering and Physics, Amsterdam University Medical Centers, Amsterdam, Netherlands, 3Spinoza Centre for Neuroimaging, Royal Netherlands Academy for Arts and Sciences, Amsterdam, Netherlands, 4Full Brain Picture Analytics, Leiden, Netherlands, 5Computational and Cognitive Neuroscience and Neuroimaging, Netherlands Institute for Neuroscience, Amsterdam, Netherlands, 6Cognitive and Systems Neuroscience Group, Swammerdam Institute for Life Sciences, Amsterdam, Netherlands, 7Research Priority Area Amsterdam Brain and Cognition, University of Amsterdam, Amsterdam, Netherlands, 8Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Amsterdam, Netherlands, 9Integrative Model-Based Cognitive Neuroscience Unit, University of Amsterdam, Amsterdam, Netherlands

Synopsis

Keywords: Microstructure, Brain, Histology

Motivation: The human cerebellum is relevant across cognitive domains. However, in-vivo cerebellar MRI measures are lacking, due to resolution/analysis constraints. Consequently, the cerebellar morphology and its links to cytoarchitecture are unexplored, thus limiting neuroscientific research.

Goal(s): To develop in-vivo cerebellar cortical measures and probe their biological relevance.

Approach: We combined motion-corrected, RF-shimmed, 7T-MRI with a novel segmentation pipeline. We extracted regional cytoarchitectonic features from 3D-reconstructed histological and immunohistochemical data.

Results: Regional differences in cerebellar cortical thickness correlated with granular layer cell density, while vascular measures also correlated with cortical thickness and cytoarchitecture.

Impact: The detailed human cerebellar morphology is unexplored. Here, we combine motion-corrected, RF-shimmed 7T-MRI with a novel segmentation approach to demonstrate links between in-vivo/post-mortem cerebellar morphology, vasculature and cytoarchitecture. This may provide insights into the pathology of several neurological disorders.

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Keywords