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Abstract #0150

Quantum Dipole Interactions Within Transient Hydrogen Bonds (THB) Define T1 Signal and Anisotropy in Neuronal Tissue. Theory and Validation.

Dmitriy A Yablonskiy1, Alexander L Sukstanskii1, and James D Quirk1
1Radiology, Washington University in St. Louis, St. Louis, MO, United States

Synopsis

Keywords: Microstructure, Relaxometry, Signal modeling, microstructure, T1 anisotropy

Motivation: MRI relaxometry is a powerful tool in research and clinical applications. However, despite more than 50-year history of applications, biophysical mechanisms of relaxation processes are not well understood.

Goal(s): To refine and validate recently proposed Transient Hydrogen Bond (THB) theory of T1 signal relaxation and anisotropy in neuronal tissue.

Approach: Inversion recovery (IR) experimental data from excised porcine spinal cord with multiple cord orientations with respect to magnetic field B0 were analyzed using THB theory.

Results: THB model produced an excellent fit to all IR experimental data, quantitatively explaining T1 anisotropy and experimental IR curves with a single set of THB model parameters.

Impact: The proposed and validated Transient Hydrogen Bond (THB) model provides a novel framework linking experimental T1 relaxation measurements to the underlying structure of cellular and myelin membranes. This approach offers a new avenue for investigating the microstructure of biological tissues.

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