Abstract #0154

Water excitation may induce signal asymmetries in the bSSFP profile which affects parametric mapping

Guillaume Cheng^1,2, Berk Can Acikgoz^1,2,3, Nils M.J. Plaehn^1,2,3, and Jessica A.M. Bastiaansen^1,2

¹Department of Diagnostic, Interventional and Pediatric Radiology (DIPR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland, ²Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, Switzerland, ³Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland

Synopsis

Keywords: Multi-Contrast, Contrast Mechanisms

Motivation: Unsuppressed fat signal impairs the visualization of small anatomical structures and the quantification of relaxation times. Phase-cycled bSSFP can map both T1 and T2 relaxation times but not when fat is within the same voxel.

Goal(s): To test the effect of different water excitation methods on relaxation time quantification and fat suppression in phase-cycled bSSFP.

Approach: Conventional and off-resonant water excitation pulses were implemented in phase-cycled bSSFP sequences and experiments were performed in phantoms and knees of healthy subjects.

Results: A few water excitation approaches were excellent while others induced signal asymmetries in the bSSFP profile, which affected T1 and T2 mapping.

Impact: Using advanced water excitation pulses enabled fat-free multiparametric mapping with phase-cycled bSSFP. This benefits relaxometry that may be confounded by fat, which is particularly interesting for quantitative imaging in pathologies such as metabolic dysfunction-associated steatotic liver disease, where fat accumulates.

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