Abstract #0160

Ultrashort echo time magnetization transfer (UTE-MT) MRI detects non-enzymatic crosslinking of collagen in ex vivo rat bones

Soo Hyun Shin¹, Dina Moazamian¹, Kaixin Pan^2,3, Qingbo Tang^1,4, Saeed Jerban¹, Yajun Ma¹, Eric Y. Chang^1,4, Sameer Shah^2,3, Nigel Calcutt⁵, Robert Sah², Jeremy Pettus⁶, Gina Woods⁶, and Jiang Du^1,2,4

¹Department of Radiology, UC San Diego, La Jolla, CA, United States, ²Department of Bioengineering, UC San Diego, La Jolla, CA, United States, ³Department of Orthopedic Surgery, UC San Diego, La Jolla, CA, United States, ⁴Radiology Service, VA San Diego Healthcare System, La Jolla, CA, United States, ⁵Department of Pathology, UC San Diego, La Jolla, CA, United States, ⁶Department of Medicine, UC San Diego, La Jolla, CA, United States

Synopsis

Keywords: Bone/Skeletal, Diabetes

Motivation: Type 2 diabetes (T2D) patients suffer from increased bone fracture risk despite preserved or even elevated bone mineral density (BMD). A better diagnostic tool that accurately reports the bone health of T2D patients is urgently needed.

Goal(s): To develop an MRI method that can probe non-enzymatic crosslinking of bone collagen and compromise of bone mechanical properties.

Approach: We used ultrashort echo time magnetization transfer (UTE-MT) MRI for measuring the degree of collagen crosslinking in ex vivo rat bones with ribosylation.

Results: The UTE-MT showed sensitivity to bone collagen crosslinking via ribosylation and subsequent compromise of bone mechanical properties.

Impact: The UTE-MT technique showed significant sensitivity to non-enzymatic crosslinking of bone collagen, a key mechanism that explains the increased fracture risk of T2D patients. The UTE-MT can be an accurate noninvasive diagnostic tool for probing bone health of T2D patients.

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