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Abstract #0167

Placental contractions in healthy and compromised placentas

Amy Turnbull1, George Hutchinson1, Ruizhe Li2, Louise Dewick3, Christopher Bradley1,4, Craig Platt5, Neele Dellschaft1, Kate Walker3, Nia Jones3, Xin Chen2, Grazziela Figueredo2, and Penny Gowland1
1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2School of Computer Science, University of Nottingham, Nottingham, United Kingdom, 3School of Medicine, University of Nottingham, Nottingham, United Kingdom, 4National Institute for Health Research, Biomedical Research Centre, Hospital NHS Trust and University of Nottingham, Nottingham, United Kingdom, 5Nottingham University Hospital Trust, Nottingham, United Kingdom

Synopsis

Keywords: Placenta, Placenta, Dynamic MRI, BOLD, pregnancy

Motivation: Placental contractions will have an impact on the blood flow through the placenta and therefore the health of the fetus. However they have not been fully characterised and have never been studied in compromised pregnancies.

Goal(s): Characterise contractions in healthy placentas and compare to compromised pregnancies.

Approach: Dynamic respiratory triggered EPI for 10-30 minutes to measure changes in placental shape and BOLD signal.

Results: All groups displayed placental contractions and differences in the depth and length of contractions was observed in compromised pregnancies.

Impact: A third of stillbirths are caused by placental complications. Placental contractions are a newly identified physiological phenomenon and so it is important to understand any role they may play in compromised pregnancies.

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