Meeting Banner
Abstract #0187

CEST Imaging Combined with 1H-MRS Reveal the Neuroprotective Effects of Riluzole by Improving Neurotransmitter Imbalances in 3xTg AD Mice

Yuanyu Shen1, Siqi Liu1, Xiaolei Zhang1, Wentao Xuan1, Caiyu Zhuang1, Yue Chen1, Beibei Chen1, Xinhui Zheng1, and Yan Lin1
1Second Affiliated Hospital of Shantou University Medical College, Shantou, China

Synopsis

Keywords: Alzheimer's Disease, Molecular Imaging

Motivation: Glutamate (Glu) and gamma-aminobutyric acid (GABA) imbalance plays a significant role in Alzheimer's disease (AD) pathogenesis. Whether riluzole can improve neurotransmitter homeostasis in AD brain remains unclear.

Goal(s): Using CEST imaging and 1H-MRS to monitor Glu/GABA changes in riluzole-treated AD mice and evaluate riluzole's efficacy and mechanism.

Approach: Measured Glu/GABA levels using GluCEST, GABACEST, and 1H-MRS in riluzole-treated 3xTg AD mice. Assessed cognition brain pathology, neuronal survival, and protein expression.

Results: Riluzole increased GluCEST/GABACEST signals, elevated Glu/GABA levels in AD mice, correlating with improved cognition. Riluzole reduced AD-related pathology, increased neuronal survival, and restored Glu/GABA-related protein expression.

Impact: This study highlights the potential of combining CEST imaging and 1H-MRS as a non-invasive approach to evaluate riluzole’s effects on Glu/GABA metabolism and cognitive function in AD mice, providing a promising neuroimaging tool for assessing AD therapies.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords