Abstract #0190

Influence of microglial activation on neuronal metabolism in Alzheimer’s disease: A hybrid 3D-MRSI/PET study

Yaoyu Zhang^1,2, Jialin Hu¹, Xiao-Hang Qian³, Miao Zhang⁴, Yibo Zhao⁵, Yudu Li^5,6,7, Wen Jin^5,8, Chang Xu¹, Huixiang Zhuang¹, Ziyu Meng^1,2, Wenli Li¹, Siyue Chen³, Xu-Feng Jiang⁴, Zhi-Pei Liang^5,8, Biao Li⁴, Huidong Tang³, and Yao Li^1,2

¹National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy (NERC-AMRT), School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ²Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai, China, ³Department of Geriatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ⁴Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ⁵Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁶National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁷Department of bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁸Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease

Motivation: To understand the influence of microglial activation on neuronal metabolism across prodromal AD and AD dementia stages.

Goal(s): To investigate the whole-brain relationship between microglial activation and neuronal metabolism at regional and voxel levels.

Approach: A combined [¹⁸F]DPA-714 PET and 3D-MRSI (resolution: 2×3×3 mm³) was used to simultaneously map whole-brain levels of N-acetylaspartate and microglial activation in cognitively normal (CN), prodromal AD and AD dementia patients.

Results: Correlations between microglial activation and N-acetylaspartate shift markedly, from predominantly positive in parietal and anterior cingulate cortices in CN to predominantly negative in frontal and temporal cortices in AD.

Impact: Using a hybrid 3D-MRSI/PET approach, we identified a biphasic effect of microglial activation on neuronal metabolism across healthy, prodromal AD and AD dementia stages. This approach provides a valuable tool for evaluating neuroinflammation and neuronal integrity throughout AD progression.

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