Abstract #0193

Mapping the Influence of Amyloid, Tau, and APOE Variants on White Matter Tracts in Alzheimer’s Disease

Bramsh Qamar Chandio¹, Julio E Villalon-Reina¹, Talia M Nir¹, Sophia I Thomopoulos¹, Yixue Feng¹, Sebastian Benavidez¹, Neda ahanshad¹, Jaroslaw Harezlak², Eleftherios Garyfallidis³, and Paul M Thompson¹

¹Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Marina del Rey, CA, United States, ²Department of Epidemiology and Biostatistics, Indiana University Bloomington, Bloomington, IN, United States, ³Department of Intelligent Systems Engineering, Indiana University Bloomington, Bloomington, IN, United States

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease, Diffusion MRI, Tractometry, Tractography, BUAN, White Matter Tracts, Microstructure, Amyloid, Tau, ApoE

Motivation: Alzheimer’s disease (AD) biomarkers like amyloid, tau, and APOE variants impact brain white matter tracts, potentially revealing AD progression pathways.

Goal(s): Examine how these biomarkers affect microstructure of white matter tracts, aiding in AD tracking and prediction.

Approach: Using diffusion MRI from 730 ADNI3 participants, we applied BUndle ANalytics (BUAN) tractometry to analyze biomarker-related microstructural differences along specific white matter tracts.

Results: Amyloid positivity increased diffusivity in key tracts, tau showed stronger associations with Mean diffusivity (MD) near cortical regions, and APOE ϵ4 carriers exhibited greater microstructural changes. These findings emphasize MD’s potential for early detection and monitoring of Alzheimer’s disease progression.

Impact: Our findings highlight the role of tau, amyloid, and APOE variants in disrupting brain connectivity, shedding light on Alzheimer's disease pathology and localized white matter tract changes.

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