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Abstract #0195

Cerebrovascular reactivity mapping without gas inhalation: signal characterization with multi-echo BOLD

Oluwateniola Sophia Akinwale1, Zhiyi Hu1, Essa Yacoub2, Peiying Liu3, and Hanzhang Lu1
1Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Center for MR Research (CMRR), University of Minnesota, Minneapolis, MN, United States, 3Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Task/Intervention Based fMRI, Vascular, cerebrovascular reactivity; breath modulation; end-tidal CO2

Motivation: Cerebrovascular reactivity (CVR) has shown strong promise in large-vessel stenotic diseases and small-vessel-related cognitive impairment and dementia. Conventional CVR MRI requires CO2 inhalation inside the scanner. Recently, a gas-free technique was proposed based on breath modulations.

Goal(s): To characterize the signal underpinnings of breath-modulation CVR MRI using multi-echo BOLD acquisition.

Approach: We examined the relationships among multi-echo CVR, end-tidal (Et) CO2, and a gold-standard blood flow response to CO2 inhalation.

Results: T2* changes measured with multi-echo showed strong correlation with EtCO2, and were highly correlated with the gold-standard CO2-inhalation CVR. Breath-modulation data can be used to estimate a bolus-arrival-time map.

Impact: Breath-modulation resulted in an EtCO2 reduction by ~2.5mmHg. In terms of the BOLD acquisition sequences, ME-BOLD T2* CVR yielded a similar precision as the SG-BOLD, but with higher accuracy. Breath-modulation MRI can also yield reliable bolus arrival time maps.

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Keywords