Abstract #0202

Investigation of sustained blood flow and metabolic changes in the healthy brain following motor learning

Davide Di Censo^1,2, Stefano Censi^1,2, Francesca Graziano^1,2, Eleonora Patitucci³, Manuela Carriero^1,2, Sara Pomante^1,2, Federica Procida^1,2, Federica Tomaiuolo^2,4, Maria Giulia Tullo^1,2, Michael Andrew Germuska⁵, Emma Biondetti^1,2, Alessandra Stella Caporale^1,2, Antonio Maria Chiarelli^1,2, Valentina Tomassini^1,2, and Richard Geoffrey Wise^1,2

¹Department of Neurosciences, Imaging, and Clinical Sciences, University 'G. D'annunzio' of Chieti-Pescara, Chieti, Italy, ²Institute for Advanced Biomedical Technologies, University ‘G. D'Annunzio’ of Chieti-Pescara, Chieti, Italy, ³School of Psychology, Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff, United Kingdom, ⁴Department of Engineering and Geology, University 'G. D'annunzio' of Chieti-Pescara, Chieti, Italy, ⁵Department of Radiology, University of California Davis Medical Center, Sacramento, CA, United States

Synopsis

Keywords: fMRI Analysis, Metabolism, resting state, CMRO2, cbf, task based fMRI

Motivation: Improve our understanding of the brain’s metabolic response to motor learning in healthy adults.

Goal(s): Investigate adaptations of energy metabolism following learning on a visuomotor task with simultaneous BOLD/ASL functional imaging.

Approach: We acquired breath-hold calibrated functional MRI data before and after healthy subjects undertook motor learning on a visuomotor task to investigate potential changes of brain cerebral blood flow (CBF) and metabolic rate of oxygen (CMRO₂) sustained after the end of the task.

Results: We found significant differences in CBF and a trend towards changes in CMRO₂following completion of the task in brain areas involved in somatosensory integration and motor learning.

Impact: These results provide a framework for investigating learning-related brain blood flow and metabolic changes that may sustain long-term plasticity relevant for mitigating neurological conditions.

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