Abstract #0208

Mapping Hand Function in the Brain and Spinal Cord with Simultaneous Brain-Spinal Cord Functional MRI

Valeria Oliva^1,2, Sandrine Bédard^2,3, Andrew C Smith⁴, Merve Kaptan², Dario Pfyffer², Brett Chy², Susanna Aufrichtig², Nazrawit Berhe², John Ratliff⁵, Serena Hu⁶, Zachary A Smith⁷, Trevor J Hastie⁸, Scott L Delp⁹, Sean Mackey², Gary H Glover¹⁰, Akshay S Chaudhari¹⁰, Christine SW Law², and Kenneth A Weber II²

¹Center for Behavioral Sciences and Mental Health, Italian National Institute of Health, Rome, Italy, ²Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Palo Alto, CA, United States, ³Institute of Biomedical Engineering, Polytechnique Montréal, Montréal, QC, Canada, ⁴Department of Physical Medicine and Rehabilitation, University of Colorado School of Medicine, Aurora, CO, United States, ⁵Department of Neurosurgery, Stanford University School of Medicine, Palo Alto, CA, United States, ⁶Department of Orthopaedic Surgery, Stanford University School of Medicine, Palo Alto, CA, United States, ⁷Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States, ⁸Department of Statistics, Stanford University, Palo Alto, CA, United States, ⁹Department of Bioengineering and Mechanical Engineering, Stanford University, Palo Alto, CA, United States, ¹⁰Department of Radiology, Stanford University School of Medicine, Palo Alto, CA, United States

Synopsis

Keywords: Task/Intervention Based fMRI, Neuroscience, Corticospinal fMRI; Motor Control; Hand Function; Dexterity; Force Generation

Motivation: Hand function can be disrupted by injury to the brain, SC, and peripheral nerves leading to weakness and impaired coordination. With simultaneous brain-spinal cord (SC) fMRI, we can non-invasively assess the neural mechanisms underlying motor control of the hand.

Goal(s): Map brain and SC activity to improve our understanding of the neural correlates of hand function.

Approach: Simultaneous brain-SC fMRI was performed on twenty-eight healthy volunteers during force matching and finger tapping experiments with three task levels.

Results: Graded brain and SC activity across the task levels was identified, including activation and deactivation of sensory and motor regions.

Impact: We mapped brain and SC neural correlates of hand function showing activations and deactivations in sensory and motor regions, providing a more complete picture of motor control.

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