Abstract #0210

Early Cortical Reorganization in the Sensorimotor Network Following FES Cycling Intervention in Individuals with Chronic SCI.

Lukman E. Ismaila^1,2, Cristina L. Sadowsky³, and Ann S. Choe^1,2

¹Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³International Center for Spinal Cord Injury, Kennedy Krieger Institute, Baltimore, MD, United States

Synopsis

Keywords: Functional Connectivity, fMRI (resting state), Spinal Cord, Graph Theory

Motivation: We aimed to fill the knowledge gap regarding the cortical reorganization within Sensorimotor after FES cycling intervention.

Goal(s): We sought to investigate early connectivity changes in individuals with chronic SCI, after intervention.

Approach: We implemented graph theory technique to analyze resting state fMRI data, this approach quantifies brain regions to evaluate functional connectivity changes between SCI intervention period.

Results: Significant connectivity changes were observed within the sensorimotor network at post-FES stage. Increased RC and IC values across SMN-1 and SMN-2 regions suggest enhanced intra-network and inter-network connectivity respectively within the segregated sensorimotor network while motor scores remain unmeasurable.

Impact: Our findings reveal FES-induced reorganization within the sensorimotor network of the SCI group at the post-FES stage. This could guide clinicians, researchers, and rehabilitation specialists in using rs-fMRI to observe early cortical changes, even when measurable motor improvements are absent.

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