Keywords: Neurofluids, Neurofluids, Brain clearance; BOLD-CSF; CSF flow
Motivation: Inflow-sensitized BOLD-CSF coupling analysis is corrupted by spin history effects where CSF-outflow measurements affect subsequent inflow measurements and vice versa. A method that can measure bi-directional flow and simultaneous cortical BOLD is required for accurate estimation of BOLD-CSF dynamics.
Goal(s): To develop an easily implementable, fast, bi-directional alternative for BOLD-CSF coupling measurements.
Approach: Using sagittal scans in combination with a saturation slab instead of axial scanning.
Results: The new technique provides in- and outflow CSF-measurements in the fourth ventricle. BOLD-CSF coupling was found to be comparable between the new bi-directional sagittal and original axial method.
Impact: Interest in BOLD-CSF coupling is increasing in clinical studies as a measure of brain clearance efficiency. We propose a new bi-directional sagittal approach that could give more robust BOLD-CSF coupling and later potentially quantitative bi‑directional CSF-flow extending on modelling approaches.
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