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Abstract #0245

Bidirectional BOLD-CSF coupling using sagittal BOLD imaging with additional saturation slab for glymphatic function assessment

Emiel C. A. Roefs1,2, Ingmar Eiling1, Nina E. Fultz1, Lydiane Hirschler1, and Matthias J.P. van Osch1
1C.J. Gorter MRI Center, Radiology, Leiden UMC, Leiden, Netherlands, 2Neuroscience Theme, Leiden UMC, Leiden, Netherlands

Synopsis

Keywords: Neurofluids, Neurofluids, Brain clearance; BOLD-CSF; CSF flow

Motivation: Inflow-sensitized BOLD-CSF coupling analysis is corrupted by spin history effects where CSF-outflow measurements affect subsequent inflow measurements and vice versa. A method that can measure bi-directional flow and simultaneous cortical BOLD is required for accurate estimation of BOLD-CSF dynamics.

Goal(s): To develop an easily implementable, fast, bi-directional alternative for BOLD-CSF coupling measurements.

Approach: Using sagittal scans in combination with a saturation slab instead of axial scanning.

Results: The new technique provides in- and outflow CSF-measurements in the fourth ventricle. BOLD-CSF coupling was found to be comparable between the new bi-directional sagittal and original axial method.

Impact: Interest in BOLD-CSF coupling is increasing in clinical studies as a measure of brain clearance efficiency. We propose a new bi-directional sagittal approach that could give more robust BOLD-CSF coupling and later potentially quantitative bi‑directional CSF-flow extending on modelling approaches.

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Keywords