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Abstract #0248

SORDINO for mapping glymphatic dynamics and choroid plexus efflux

SungHo Lee1,2,3, Tzu-Wen Winnie Wang1,2, Martin J. MacKinnon1,2, Sheng Song1,2, Siddhi S. Ozarkar4,5, Mark D. Shen4,5,6, Benjamin D. Philpot4,5,7, and Yen-Yu Ian Shih1,2,3
1Center for Animal MRI, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 2Biomedical Research Imaging Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 3Department of Neurology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 4Carolina Institute for Developmental Disabilities, The University of North Carolina at Chapel hill, Chapel Hill, NC, United States, 5Neuroscience Center, The University of North Carolina at Chapel hill, Chapel Hill, NC, United States, 6Department of Psychiatry, The University of North Carolina at Chapel hill, Chapel Hill, NC, United States, 7Department of Cell Biology and Physiology, The University of North Carolina at Chapel hill, Chapel Hill, NC, United States

Synopsis

Keywords: Neurofluids, Neurofluids, Contrast Agents, Preclinical, Small Animal, segmentation

Motivation: This study is motivated by the need for advanced imaging tools to non-invasively map CSF dynamics, essential for understanding neurodegenerative disease mechanisms and developing targeted therapies.

Goal(s): This study aims to establish SORDINO as a versatile tool for imaging fluid dynamics in the brain.

Approach: Using SORDINO, a silent, motion-resistant T1-sensing sequence with contrast agents (Gd, Mn), we dynamically segmented critical brain regions in preclinical models. Kinetic parameters derived from the Empirical Mathematical Model (EMM) demonstrated SORDINO’s effectiveness in capturing fluid kinetics.

Results: SORDINO successfully segmented brain regions involved in CSF dynamics, demonstrating precise kinetic profiling and potential for advanced CNS imaging applications.

Impact: This study pioneers the use of SORDINO MRI, a silent, distortion-free, motion-insensitive, and efficient T1-sensing sequence, to map glymphatic dynamics or choroid plexus efflux, enabling functional segmentation of brain ventricular spaces and the choroid plexus for studying brain fluid dynamics.

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Keywords