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Abstract #0251

Probing Glymphatic Exchange Between CSF and Tissue Using Long-TE Arterial Spin Labeling: Simplified Model and Shorter Scan Time

Zihan Wang1, Zhiyi Hu1, Dengrong Jiang2, Dinil Sankaralayam2, Hongli Fan1, Jie Song1, Yifan Gou1, Wen Shi1, Yulin Ge3, and Hanzhang Lu1,2,4
1Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, 2Radiology, Johns Hopkins University, Baltimore, MD, United States, 3Radiology, NYU Grossman School of Medicine, New York, NY, United States, 4F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Synopsis

Keywords: Neurofluids, Neurofluids, Glymphatic System, ASL, Blood, CSF

Motivation: There is currently not a clinically feasible imaging technique for the evaluation of glymphatic function.

Goal(s): We proposed a new framework to measure a simple index, CSF signal fraction in ASL, which only requires 10 minutes of scan time using a single delay and two echoes.

Approach: Compared to standard pCASL, the proposed sequence used enhanced background suppression, complex control and label subtraction, and a T2-preparation module with a long effective TE(eTE).

Results: The parametric map had a variability of approximately 5%. An eTE of ≥480ms and a PLD of ≥2500ms are suitable for CSF fraction mapping.

Impact: In this study, we developed a framework to measure CSF signal fraction in ASL MRI, which may provide a physiological index to evaluate tissue CSF dynamics and brain waste clearance system.

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Keywords