Keywords: Neurofluids, Neurofluids, Glymphatic System, ASL, Blood, CSF
Motivation: There is currently not a clinically feasible imaging technique for the evaluation of glymphatic function.
Goal(s): We proposed a new framework to measure a simple index, CSF signal fraction in ASL, which only requires 10 minutes of scan time using a single delay and two echoes.
Approach: Compared to standard pCASL, the proposed sequence used enhanced background suppression, complex control and label subtraction, and a T2-preparation module with a long effective TE(eTE).
Results: The parametric map had a variability of approximately 5%. An eTE of ≥480ms and a PLD of ≥2500ms are suitable for CSF fraction mapping.
Impact: In this study, we developed a framework to measure CSF signal fraction in ASL MRI, which may provide a physiological index to evaluate tissue CSF dynamics and brain waste clearance system.
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