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Abstract #0261

Pan-Contrast Learning of MRI Segmentation for Healthy and Anomaly Cases: Faithful to Tissue Properties and MR Physics

Rhea Adams1, Walter Zhao1, Siyuan Hu1, Wenjiao Lyu2, Khoi Minh Huynh2, Sahar Ahmad2, Dan Ma1, and Pew-Thian Yap2
1Case Western Reserve University, Cleveland, OH, United States, 2University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

Synopsis

Keywords: Analysis/Processing, MR Fingerprinting/Synthetic MR, Age-Agnostic, Pan-Contrast, Cross-Vendor, Cross-Site, Anomaly, Variable-Resolution, Whole-Brain

Motivation: Current MRI segmentation methods are limited to certain scan types or do not consider MR physics, which negatively affects segmentation quality in some cases.

Goal(s): Learn and validate pan-contrast MRI segmentation.

Approach: We introduce a framework that accurately reflects tissue properties and MR physics in generating images for all MR sequences using randomized scanning and noise parameters, to aid learning and validation of pan-contrast segmentation.

Results: UltBrainNet outperforms the state-of-the-art in 87% of labels for conventional MR images. UBN generalizes across the human lifespan, including challenging neonate cases, and outperforms the SOTA in 100% of labels for low-resolution, variable-orientation, and pathology cases.

Impact: UBN offers a comprehensive solution for consistent segmentation across all MR image contrasts, vendors, resolutions, sites, preprocessing methods, and age groups.

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Keywords