Keywords: High-Field MRI, Brain, Quality metrics, high-field MRI, brain, pulse sequence
Motivation: Downfield magnetic resonance spectroscopic imaging (DF-MRSI) at high magnetic field strengths is expected to have superior signal-to-noise ratios (SNR) and spectral resolution compared to lower field. However, to date there have been no studies systematically comparing DF-MRSI across different field strengths.
Goal(s): To quantitatively compare SNR, linewidths, and Cramér-Rao Lower Bounds (CRLB) for amide resonances in the human brain measured at 3 and 7T using (DF-MRSI).
Approach: Seven healthy volunteers were scanned at 3T and 7T using closely-matched DF-MRSI protocols.
Results: DF-MRSI at 7T showed 86% increased SNR and 57% decreased CRLB values compared to 3T. Water linewidths were narrower at 3T.
Impact: Amide mapping using DF-MRSI at 7T showed significantly superior precision compared to 3T, and therefore is the preferred field strength for future research studies of DF metabolites.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords