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Abstract #0270

Mesoscale T2*-weighted MRI of the human cerebellum at 10.5 Tesla: initial experience

Shuxian Qu1, Jacco A. de Zwart2, Peter Van Gelderen2, Jeff H. Duyn2, Andrea Grant1, Alexander Bratch1, Edward Auerbach1, Matt Waks1, Russell Lagore1, Lance Delabarre1, Alireza Sadeghi Tarakameh1, Yigitcan Eryaman1, Gregor Adriany1, Kamil Ugurbil1, Gulin Oz1, Xiaoping Wu1, and Jiaen Liu3,4
1CMRR, Radiology, Medical School, University of Minnesota, Minneapolis, MN, United States, 2Advanced MRI section, NINDS, NIH, Bethesda, MD, United States, 3Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 4Radiology, UT Southwestern Medical Center, Dallas, TX, United States

Synopsis

Keywords: High-Field MRI, High-Field MRI

Motivation: There is an increasing interest in pursuing ultrahigh resolution human cerebellum MRI at ultrahigh field capitalizing on the increased SNR and CNR.

Goal(s): To demonstrate the feasibility and utility of mesoscale T2*-weighted cerebellum MRI at 10.5T by synergizing various techniques.

Approach: Data were collected at 0.4-mm isotropic resolution with tailored RF shimming, a custom high density head RF array, and fast motion-robust multi-echo 3D EPI. SWI, quantitative R2* and local field maps were obtained.

Results: Our approach produced high quality images, delineating fine cerebellar architecture with improved SNR and contrast.

Impact: The demonstrated feasibility and utility of motion-robust mesoscale multi- echo EPI in humans at 10.5T may shed light on future optimal implementation of anatomical T2*-weighted cerebellum MRI at ultrahigh field, paving the way for future neuroscience applications.

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Keywords