Keywords: Stroke, Neurofluids, atherosclerosis, CSF flow, glympahtic system
Motivation: Pulsatile cerebrospinal fluid (CSF) flow alterations in ischemic stroke patients remains unknown.
Goal(s): To investigate alterations in CSF pulsation in stroke patients with unilateral middle cerebral artery atherosclerotic stenosis.
Approach: We recruited 97 patients with unilateral M1 segment stenosis and used dynamic diffusion-weighted imaging (dynDWI) to assess pCSF pulsation surrounding major cerebral arteries.
Results: A significant 12% reduction in pulsatile pCSF volume was observed in the stenotic hemisphere compared to the control side. Patients with more severe stenosis exhibited a greater reduction, primarily downstream of the stenotic site.
Impact: Our findings provide human evidence that arterial stenosis reduces pCSF pulsatility, suggesting a dual consequence for cerebrovascular conditions, affecting both blood flow and CSF flow.
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