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Abstract #0275

Reduced perivascular cerebrospinal fluid pulsation in patients with ischemic stroke

Qiuting Wen1, Xiaopeng Zhou2, Caixia Fu3, Bing Tian4, and Chengcheng Zhu5
1Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, 2Purdue University, School of Health Sciences, West Lafayette, IN, United States, 3Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, 4Department of Radiology, Changhai Hospital, Shanghai, China, 5Department of Radiology, University of Washington School of Medicine, Seattle, China

Synopsis

Keywords: Stroke, Neurofluids, atherosclerosis, CSF flow, glympahtic system

Motivation: Pulsatile cerebrospinal fluid (CSF) flow alterations in ischemic stroke patients remains unknown.

Goal(s): To investigate alterations in CSF pulsation in stroke patients with unilateral middle cerebral artery atherosclerotic stenosis.

Approach: We recruited 97 patients with unilateral M1 segment stenosis and used dynamic diffusion-weighted imaging (dynDWI) to assess pCSF pulsation surrounding major cerebral arteries.

Results: A significant 12% reduction in pulsatile pCSF volume was observed in the stenotic hemisphere compared to the control side. Patients with more severe stenosis exhibited a greater reduction, primarily downstream of the stenotic site.

Impact: Our findings provide human evidence that arterial stenosis reduces pCSF pulsatility, suggesting a dual consequence for cerebrovascular conditions, affecting both blood flow and CSF flow.

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