Abstract #0277

White matter integrity associated with residual ventral stream function after posterior cerebral artery stroke

Yuheng Zeng^1,2, Sara Ajina¹, Alexander P. Leff³, Matthew A. Lambon Ralph⁴, and Randi Starrfelt⁵

¹Wellcome Centre for Human Neuroimaging, Queen Square Institute of Neurology, University College London, London, United Kingdom, ²Neuroimage Analytics Laboratory and Biggs Institute Neuroimaging Core, Glenn Biggs Institute for Neurodegenerative Disorders, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States, ³UCL Queen Square Institute of Neurology and Institute of Cognitive Neuroscience, University College London, London, United Kingdom, ⁴MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom, ⁵Department of Psychology, University of Copenhagen, Copenhagen, Denmark

Synopsis

Keywords: Stroke, Stroke, Visual function

Motivation: Microstructural changes of white matter tracts on ventral stream function deficits after posterior cerebral artery (PCA) stroke remain poorly understood.

Goal(s): This study investigates the association between the integrity of six essential white matter tracts and residual ventral stream functions in PCA stroke survivors.

Approach: We used tractography and diffusion tensor imaging (DTI) to assess microstructural integrity along tracts of interest, with principal component analysis to capture significant spatial variations for white matter microstructure.

Results: White matter integrity correlates with residual ventral stream functions, specifically in colour perception, fine shape discrimination, and face recognition.

Impact: This study demonstrates that applying principal component analysis to along-tract DTI metrics is an effective approach to evaluate white matter integrity, aiding in the assessment of ventral stream function loss after stroke.

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