Abstract #0281

A compact approach combining Multi-Delay pCASL with short and long delays for clinical applications

Makoto Obara¹, Osamu Togao², Tatsuhiro Wada³, Chiaki Tokunaga³, Lena Václavů⁴, Matthias J.P. van Osch⁴, Shota Ishida⁵, Yu Ueda¹, Masami Yoneyama¹, Jihun Kwon¹, and Marc Van Cauteren¹

¹Philips Japan, Tokyo, Japan, ²Department of Molecular Imaging & Diagnosis, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ³Division of Radiology, Department of Medical Technology, Kyushu University Hospital, Fukuoka, Japan, ⁴C.J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁵Department of Radiological Technology, Faculty of medical sciences, Kyoto College of Medical Science, Kyoto, Japan

Synopsis

Keywords: Stroke, Arterial spin labelling, Multi-Delay, Multi-Timepoints

Motivation: While interest in multi-delay pseudo-continuous arterial spin labelling (MD-pCASL) is growing, the clinical need for efficient acquisition and visualisation of both short and longer delay times has not been technically established.

Goal(s): The goal is to validate short (500 ms) to long (5000 ms) delay combined compact approach MD-pCASL schemes in terms of SNR and quantification.

Approach: Three schemes, sequential variable-TR (vTR, 2min 57sec), single-control fixed-TR (fixTR, 2min 25sec) and a hybrid of vTR and time-encoded (Hybrid, 2min 51sec) were implemented and compared on SNR and quantitative values.

Results: Highest SNR and reasonable quantitative values were obtained by Hybrid scheme.

Impact: Hybrid MD-ASL was shown to cover short to long delays and demonstrated superior in terms of higher SNR, measuring reasonable quantitative parameters, and scan time. Use of the scheme in neurovascular and neuro-oncology applications is expected to be advantageous.

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