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Abstract #0284

Functional Glutamate and GABA response maps to visual stimulation by functional magnetic resonance spectroscopic imaging

André Döring1,2, Zhiwei Huang1,2, Antonia Kaiser1,2, Karl Landheer3,4, Uzay Emir5, and Lijing Xin1,2
1CIBM Center for Biomedical Imaging, Lausanne, Switzerland, 2Animal Imaging and Technology, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 3Department of Biomedical Engineering, Columbia University, New York, NY, United States, 4Regeneron Genetics Center, Tarrytown, NY, United States, 5Department of Radiology, University of North Carolina at Chapell Hill, Chapel Hill, NC, United States

Synopsis

Keywords: fMRI Acquisition, fMRI Acquisition, Spectroscopy, Neurotransmitters, Spectroscopic Imaging

Motivation: Modulations in brain neurotransmitters are crucial in brain function, but have remained accessible only with single voxel MR spectroscopy.

Goal(s): We aim to develop a technique to measure functional changes of inhibitory (GABA) and excitatory (Glu) neurotransmitters at high spatio-temporal resolution.

Approach: We implemented editing fMRSI, extended by a rosette trajectory readout, an optimized water suppression and crushing schemes, and a reconstruction addressing k-space distortions.

Results: We present, for the first time, high resolution maps of GABA and Glu modulated in response to a visual-stimulus, showing increases of GABA in the thalamus and visual cortex, and increases of Glx in the visual cortex.

Impact: The proposed fMRSI method offers a novel functional imaging tool for accessing unprecedented metabolic insights underlying brain function in health and diseases.

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Keywords