Abstract #0289

SORDINO fMRI: contrast mechanisms and applications in awake behaving mice

Sheng Song^1,2,3, Martin J. Mackinnon^1,2,3, Tzu-Hao Harry Chao^1,2,3, Li-Ming Hsu^1,2,3,4, Scott T. Albert⁵, Tatiana A. Shnitko^1,2,3, Tzu-Wen Winne Wang^1,2, Randy Nonneman^1,2,3, Usay E. Emir^1,2,4, Adam W. Hantman⁵, Sung-Ho Lee^1,2,3, Wei-Tang Chang^2,4, and Yen-Yu Ian Shih^1,2,3

¹Center for Animal Magnetic Resonance Imaging, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ²Biomedical Research Imaging Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ³Department of Neurology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ⁴Department of Radiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ⁵Neuroscience Center and Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

Synopsis

Keywords: fMRI Acquisition, fMRI Acquisition, fMRI (task based), fMRI (resting state), Preclinical, Contrast Mechanism

Motivation: Current fMRI techniques like GRE-EPI suffer from acoustic noise, motion artifacts, and specificity, limiting their use, especially in awake “behaving” animal studies.

Goal(s): To establish an fMRI method that minimizes noise and artifacts while boosting sensitivity and specificity for improved functional brain mapping.

Approach: We developed SORDINO (Steady-state On-the-Ramp Detection of INduction-decay with Oversampling) on a 9.4T MRI system, utilizing a constant gradient amplitude and continuous directional change throughout, and directly samples FID with maximal acquisition efficiency.

Results: SORDINO outperformed conventional methods, offering silent, artifact-resistant imaging with robust sensitivity, enabling high-quality functional brain mapping in awake behaving mice.

Impact: This study introduces SORDINO, a transformative fMRI technique that measures non-BOLD contrast. SORDINO enables precise, artifact-resistant, sensitive, and silent brain mapping in awake behaving subjects, enabling neuroimaging studies that were previously challenging or impossible.

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