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Abstract #0295

A Comparison of the 1-Point Dixon, Multiple Echo IDEAL, and Chemical Shift Imaging methods for Hyperpolarized 129Xe Spectroscopic Imaging

Riley B Meyer1, Marrissa J McIntosh2, Keegan R Staab1, Jonathan L Percy3, Olajumoke A Aboderin1, Saman Khodaei1, Abhilash S. Kizhakke Puliyakote2, Rolf F Schulte4, Conner J Wharff2, Sean B Fain1,2, and Andrew D Hahn2
1Roy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa City, IA, United States, 2Department of Radiology, University of Iowa, Iowa City, IA, United States, 3Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 4GE HealthCare, Munich, Germany

Synopsis

Keywords: Hyperpolarized MR (Gas), Hyperpolarized MR (Gas)

Motivation: Hyperpolarized 129Xe gas-exchange imaging techniques are not yet standardized across sites.

Goal(s): To determine whether 1-Point Dixon, ME IDEAL, and CSI produce equivalent results.

Approach: Hyperpolarized 129Xe MRI gas-exchange was measured in eight healthy participants using the 1-Point Dixon technique, and compared with either ME IDEAL or CSI, based on random assignment, in the same participant.

Results: There was overall agreement between 1-Point Dixon and ME IDEAL and CSI with both global and regional measures of 129Xe gas-exchange. However, some histogram shape metrics significantly differed.

Impact: These results on a small cohort of participants provide preliminary support for equivalence between 1-Point Dixon, ME IDEAL, and CSI methods in the same healthy participant. This work shows promise for the standardization of hyperpolarized 129Xe gas-exchange imaging measures.

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Keywords