Keywords: Hyperpolarized MR (Non-Gas), Metabolism, Brain, Carbon-13
Motivation: With hyperpolarized 13C-MRI, α-keto-[1-13C]isocaproate (KIC) conversion to leucine can be probed in vivo. While static imaging has shown potential, dynamic acquisitions may enhance metabolic investigations.
Goal(s): Our goal was to develop and validate a dynamic imaging strategy to assess cerebral KIC metabolism in vivo, using an animal model of Alzheimer’s Disease (AD).
Approach: Transgenic 5xFAD (n=3) and wild-type (n=3) mice received KIC injections. Dynamic imaging of KIC’s conversion to leucine was conducted using an IDEAL spiral CSI acquisition-method.
Results: The results demonstrated rapid leucine accumulation in the brain, with a significantly higher cerebral metabolic conversion to leucine in AD mice compared to controls.
Impact: We introduce a dynamic method to measure BCAT activity in vivo, with initial results indicating increased activity in a preclinical Alzheimer's model. By enabling real-time tracking of KIC metabolism, we provide a tool for investigating metabolic alterations in neurological disorders.
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