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Abstract #0306

Ultrashort TE Imaging with Tight Intervals (δTE) for T2* Mapping in COPD: Toward a Biomarker for Lung Structural Changes

Vadim Malis1, Yoshimori Kassai2, Yoshiki Kuwatsuru1,3, Anya Mesa1, Andrew Yen1, Atul Malhotra4, Douglas Conrad4, and Mitsue Miyazaki1
1Radiology, UC San Diego, San Diego, CA, United States, 2Canon Medical, Ōtawara-shi, Japan, 3Radiology, Juntendo University, Tokyo, Japan, 4Medicine, UC San Diego, San Diego, CA, United States

Synopsis

Keywords: Lung, Lung, COPD, pulmonary

Motivation: Chronic Obstructive Pulmonary Disease (COPD) causes progressive lung damage, and periodic monitoring of these structural changes is crucial for understanding disease progression.

Goal(s): To develop a safe non-contrast MRI technique for accurate T2* mapping in COPD patients.

Approach: Three healthy subjects and two COPD patients were scanned on a 3T MRI with the δTE UTE sequence, using closely spaced δTE echoes and analyzed with mono- and bi-exponential T2* mapping.

Results: δTE UTE successfully mapped the differences in T2* between healthy and emphysema lung tissue, correlating with emphysema regions identified on CT, suggesting its potential as a biomarker tool in COPD.

Impact: The δTE UTE technique enables safe, non-ionizing imaging suitable for repeated exams in longitudinal monitoring of COPD progression. By enhancing T2* mapping sensitivity, it shows promise as a potential biomarker for detecting subtle lung changes, complementing current CT assessments.

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