Keywords: Lung, Lung, COPD, pulmonary
Motivation: Chronic Obstructive Pulmonary Disease (COPD) causes progressive lung damage, and periodic monitoring of these structural changes is crucial for understanding disease progression.
Goal(s): To develop a safe non-contrast MRI technique for accurate T2* mapping in COPD patients.
Approach: Three healthy subjects and two COPD patients were scanned on a 3T MRI with the δTE UTE sequence, using closely spaced δTE echoes and analyzed with mono- and bi-exponential T2* mapping.
Results: δTE UTE successfully mapped the differences in T2* between healthy and emphysema lung tissue, correlating with emphysema regions identified on CT, suggesting its potential as a biomarker tool in COPD.
Impact: The δTE UTE technique enables safe, non-ionizing imaging suitable for repeated exams in longitudinal monitoring of COPD progression. By enhancing T2* mapping sensitivity, it shows promise as a potential biomarker for detecting subtle lung changes, complementing current CT assessments.
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