Keywords: Lung, Lung, Duchenne muscular dystrophy;PREFUL MRI;Pediatrics
Motivation: In the setting of Duchenne muscular dystrophy (DMD), there is an urgent need for a sensitive technology for pulmonary function.
Goal(s): Our goal was to determine if PREFUL MRI could detect functional changes in children with DMD.
Approach: 41 patients with DMD and 15 healthy controls underwent PREFUL MRI. For DMD patients, pulmonary function tests were evaluated on the same day.
Results: We found ventilation defect percentage (VDP) was significantly higher in DMD with normal respiratory function compared with the healthy controls.
Impact: Our demonstration of a detectable decline in VDP suggests that PREFUL MRI might represent a new noninvasive tool for the functional assessment of lung even in the early phase of respiratory compromise in children with DMD.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords