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Abstract #0309

Characterizing respiratory dysfunction in Duchenne muscular dystrophy using phase‐resolved functional lung (PREFUL) MRI

Ke Xu1, Huayan Xu1, Yisheng Chen1, Ting Yin2, Robert Grimm3, and Yingkun Guo1
1West China Second University Hospital, Sichuan University, Chengdu, China, 2MR Research Collaborations, Siemens Healthineers Ltd., Chengdu, China, 3MR Application Predevelopment, Siemens Healthineers AG, Erlangen, Germany

Synopsis

Keywords: Lung, Lung, Duchenne muscular dystrophy;PREFUL MRI;Pediatrics

Motivation: In the setting of Duchenne muscular dystrophy (DMD), there is an urgent need for a sensitive technology for pulmonary function.

Goal(s): Our goal was to determine if PREFUL MRI could detect functional changes in children with DMD.

Approach: 41 patients with DMD and 15 healthy controls underwent PREFUL MRI. For DMD patients, pulmonary function tests were evaluated on the same day.

Results: We found ventilation defect percentage (VDP) was significantly higher in DMD with normal respiratory function compared with the healthy controls.

Impact: Our demonstration of a detectable decline in VDP suggests that PREFUL MRI might represent a new noninvasive tool for the functional assessment of lung even in the early phase of respiratory compromise in children with DMD.

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