Abstract #0320

Optimizing Diffusion Tractography Imaging with Clinically-Practical Acquisition Times on Portable, Low-Field MRI

Annabel Sorby-Adams¹, Mark Olchanyi^2,3,4, John Kirsch⁵, Ava Farnan¹, Matthew Rosen⁶, Emery Brown^2,4,7, Brian Edlow^2,5, Juan Eugenio Iglesias^5,8,9, and W. Taylor Kimberly¹

¹Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States, ²Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States, ³Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, United States, ⁴Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States, ⁵Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, ⁶Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, ⁷Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States, ⁸Centre for Medical Image Computing, University College London, London, United Kingdom, ⁹Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, United States

Synopsis

Keywords: Diffusion Acquisition, Low-Field MRI

Motivation: Portable, low-field MRI can improve the ease-of-access to neuroimaging and aid in detection of neurologic disorders. However, there is limited research on diffusion acquisition schemes and analysis of associated biomarkers for low-field MRI.

Goal(s): Develop a low-field diffusion sequence with a clinically-viable acquisition time and validate scalar diffusion measures compared to high-field imaging.

Approach: We recruited 11 healthy volunteers and performed both low- and high -field diffusion tensor imaging. We then compared diffusion measures across white matter bundles.

Results: We observed underlying bias between low- and high -field counterparts, but there was high correlation between their respective diffusion measures in white matter tracts.

Impact: Portable, low-field diffusion MRI could aid in the assessment of white matter integrity and diagnosis of neurologic disorders in regions/facilities lacking access to conventional MRI, and in clinically unstable patients unable to be transported to a centralized neuroimaging suite.

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